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There are two possibilities for this day: Biological and Technological.
Biological:
Virus Appreciation Day commemorates the Cowpox virus, which prevented people from contracting Small Pox when administered as a vaccination. In essence, one virus prevents another virus from living, replacing a deadly virus with one that is simply inconvenient.
Smallpox was a deadly disease until Edward Jenner tested his theory in 1796 by infecting an eight-year-old boy with live cowpox virus, awaiting his recovery for over ten days, then infecting him with smallpox. The boy did not get sick.
Smallpox was declared eradicated on May 3, 1980, by the United Nations. Over centuries it was responsible for millions of deaths worldwide.
Why this date over the anniversary of the first successful inoculation (May 14, 1796), Jenner's birthday (May 17, 1749), or day of death (January 26, 1823), is unknown. We cannot source if this is the anniversary of publishing his findings either.
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Technological:
Virus Appreciation Day evolved to educate people about protecting themselves from computer viruses.
Anyone with a computer will have encountered a virus, Trojans, and malware at some point. These destructive codes spread via attachments, networks, emails, phishing sites, and creative technological appeals like ransomware. Once contracted, these malicious codes can destroy years of work, hijack personal information and make your life a living hell.
For Norton's list of the eight most destructive viruses of all time, see https://uk.norton.com/norton-blog/2016/02/the_8_most_famousco.html.
As with Cowpox/Smallpox, we cannot find a release date or anniversary of any kind tied to October 3 relating to technology viruses. The first computer virus was Creeper, released in 1971 by Bob Thomas at BBN Technologies (Raytheon). This worm infected ARPANET and altered the screen display; Creeper was a test program, unlike today's malicious code.
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How you acknowledge this date, biological or technological, is up to you.
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